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It was found that once both co-stimulatory cytoplasmic domain ?cassettes?was added in combination with the TCR ?-chain to the CAR construct, transduced T cells hadthe ability to secrete and enhanced level of IL-2, INF-?, TNF-?, and GM-CSF. As can be seen in Figure 1.9, thenet effect of dividing the threshold or noAEL dose bysome total safety/uncertainty factor is that it is equivalentto selecting a substantially lower dose from the no-effectregion of the dose–response curve.

Neitherbones nor muscles could function without the attachments provided by thetendons and ligaments.

The first step is to acquire and storeall relevant data into a single database, data repository, or enterprise-level clinical datawarehouse.

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Sagittal reformatted CT image showsan air-containing abscess cavity ( arrows) in the anterior abdominalwall. The public, how-ever, does not view risk simply in probability terms.
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